Anaphylaxis: Use the Auto-Injector and Call 911

Recognize a severe allergic reaction, give epinephrine promptly as directed and prepare for emergency responders.

Adapted from a guide first written for Quebec readers: passages specific to Quebec were removed. Rules in your province may differ.

Anaphylaxis is an emergency. For trouble breathing, tongue or throat swelling, a changed voice, severe weakness, loss of consciousness or a rapid reaction involving several body systems, use the available auto-injector immediately according to its instructions and call 911.

Give epinephrine without delay

Follow the person's emergency plan and the directions printed on the auto-injector. Inject into the outer thigh, through clothing if the device permits. Record the time. An antihistamine does not replace epinephrine and must not delay emergency care.

Position and monitor

Keep the person lying down when tolerated; adapt the position for breathing difficulty, vomiting or pregnancy under dispatcher guidance. Do not let the person stand or walk. If they become unresponsive and are not breathing normally, begin CPR and use an available AED.

Second dose and transfer

If symptoms persist or return and a second auto-injector is available, follow the person's plan, device instructions and 911 guidance. Temporary improvement does not replace medical assessment because symptoms can recur.

Prepare for the future

Afterward, replace every used device, check expiry dates, review the plan with a clinician and ensure the right people know where the auto-injector is kept. Do not store epinephrine somewhere inaccessible or exposed to extreme temperatures.

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Sources and limits

Official sources are linked in the guide. Reviewed August 29, 2026; confirm current instructions and deadlines with the responsible authority.

General information based on federal and national rules; provincial rules may differ. Confirm with the official body before acting. Last reviewed : 2026-08-29.